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Società Italiana di Pneumologia 17 Giugno 2019 17 Giugno 2019
Checkpoint Inhibitor Pneumonitis Induced by Anti-PD-1/PD-L1 Therapy in Non-Small-Cell Lung Cancer: Occurrence and Mechanism Jianqiong Yin1†, Yuanjun Wu1†, Xue Yang1, Lu Gan2 and Jianxin Xue1,3,4* 1 Department of Thoracic Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China, 2 Research Laboratory of Emergency Medicine, Department of Emergency Medicine, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China, 3 Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China, 4 Laboratory of Clinical Cell Therapy, West China Hospital, Sichuan University, Chengdu, China

Immune checkpointty inhibitors (ICIs), particularly those targeting programmed death 1 (PD-1) and anti-programmed death ligand 1 (PD-L1), enhance the antitumor effect by restoring the function of the inhibited effector T cells and produce durable responses in a large variety of metastatic and late patients with non-small-cell lung cancer. Although often …

Giacomo Guglielmi 24 Agosto 2025 24 Agosto 2025

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